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The information on these pages is provided in good faith and should be treated as such. If you make use of the information, please acknowledge its source.

The International Society for Electrophysical Agents in Physical Therapy (ISEAPT) is a formal subgroup of the World Congress Physical Therapy (WCPT) and is the leading International organisation concerned primarily with Electro Physical Agents

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The Electro Physical Agents and Diagnostic Ultrasound (EPADU) group is a Professional Networks of the Chartered Society of Physiotherapy based in the UK.

Ultrasound Dose Calculation

Introduction
Pulse Ratio
Ultrasound Treatment Intensity
Size of the Lesion
Compiling the treatment dose
Examples
 

The most straightforward way to work out a particular dose of ultrasound for an individual patient is to use the combined available evidence and the flowchart below is based on just that. Following the flowchart is a piece of text that explains the process in some more detail. Both the flowchart and the text can be downloaded from the DOWNLOADS page for easier printing.
 

US Dose May 2013
 

Updated Treatment Principle
 

THE FOLLOWING TEXT IS AN EXPLANATION OF THE FLOWCHART ABOVE, AND IF YOU WANT TO CITE IT (OTHER THAN AS A WEB REFERENCE) YOU CAN USE THE Watson (2002) REFERENCE (ON THE PUBLICATIONS PAGE), AS THE TEXT IS JUST ABOUT THE SAME SO FAR AS I RECALL

Ultrasound Dose Calculations

One of the advantages of ultrasound therapy remains the reasonably broad range of trials from which effective treatment doses can be established.

In principle, there is no need for the often used 'recipe book' in which a list of conditions is produced alongside the treatment dose. One of the reasons for this is that the 'best' recipe for all the conditions one might encounter does not exist, certainly not from the evidence base. Secondly, there is effectively no need to learn a whole list of such formulas for successful application, one needs to apply the principles to the particular tissue in question, taking into account the relevant parameters.

The following 'dose calculations' offer one method (by no means the only one) by which the most likely clinically effective dose can be established. There is no guarantee the resulting dose will work, but it does offer a mechanism by which the dose which is most likely to work can be estimated.

Dose Calculation Stages

The first steps involve the decision as to which machine settings are most appropriately applied to the patients particular problem. The second stage is to bring these into an effective treatment combination.

Machine settings

There are effectively 4 things that you can change on your machine : ultrasound frequency, pulsing, power and time.

Machine Frequency

Taking into account that the most frequently available treatment frequencies are 1 and 3MHz, the option between them relates primarily to the effective treatment depth that is required.

3MHz ultrasound is absorbed more rapidly in the tissues, and therefore is considered to be most appropriate for superficial lesions, whilst the 1MHz energy is absorbed less rapidly with progression through the tissues, and can therefore be more effective at greater depth.

The boundary between superficial and deep lesions is in some ways arbitrary, but somewhere around the 2cm depth is often taken as a useful boundary. Hence, if the target tissue is within 2cm (or just under an inch) of the skin surface, 3MHz treatments will be effective whilst treatments to deeper tissues will be more effectively achieved with 1MHz ultrasound.

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Pulse Ratio

The pulse ratio determines the concentration of the energy on a time basis. The pulse ratio determines the proportion of time that the machine is ON compared with the OFF time.

Pulse Ratio

A pulse ratio of 1:1 for example means that the machine delivers one 'unit' of ultrasound followed by an equal duration during which no energy is delivered. The machine duty cycle is therefore 50%. A machine pulsed at a ratio of 1:4 will deliver one unit of ultrasound followed by 4 units of rest, therefore the machine is on for 20% of the time (some machines use ratios, and some percentages). The table below shows their equivalence:

Ultrasound Pulse Ratio and % Duty Cycle Equivalents

Mode Pulse Ratio Duty Cycle
Continuous   100%
Pulsed 1:1 50%
  1:2 33%
  1:3 25%
  1:4 20%
  1:9 10%

Ultrasound Pulsed (Duty Cycle %) modes and their selection

Most Acute       Most Chronic
Pulse 1:4 (20%) Pulse 1:3 (25%) Pulse 1:2 (33%) Pulse 1:1 (50%) Continuous (100%)

It is worthy of note that some machines offer pulse ratios for which no evidence can be identified to ascertain the effectiveness of the intervention. Pulse ratios of 1:9, 1:15 or 1:20 for example can be found on machines but with no trial evidence to support their use.

Combined 1 and 3MHz Ultrasound Dose table indicating ultrasound intensity at various tissue depths
To identify the appropriate dose to set on the machine, determine (a) the estimated depth of the lesion to be treated and (b) the intensity of ultrasound required at that depth to achieve the desired effect. The intensity to set on the machine is that which is indicated where the two columns/rows meet. 

E.g. to achieve a 0.5W cm-2 intensity at 1cm tissue depth, select 3MHz treatment option and set machine to 0.7 W cm-2.

The selection of the most appropriate pulse ratio essentially depends on the STATE of the tissues. The more acute the tissue state, the more energy sensitive it is, and appears to respond more favourably to energy delivered with a larger pulse ratio (lower duty cycle). As the tissue moves away from its acute state, it appears to respond preferentially to a more 'concentrated' energy delivery, thus reducing the pulse ratio (or increasing the duty cycle).

It is suggested that pulse ratios of 1:4 are best suited to the treatment of acute lesions, reducing this as the tissue moves towards the chronic state moving through 1:3 and 1:2 to end up with 1:1 or continuous modes. Some machines are unable to deliver the most effective treatment modes and the therapist will need to compromise the treatment dose according to the facilities that are available.

Ideally try for 1:4 or 1:3 for the ACUTE lesions, 1:2 and 1:1 for the SUBACUTE lesions and 1:1 or Continuous for the CHRONIC lesions.

It is of note that it is the state of the tissue that determines the most appropriate pulse ratio rather than simply the duration since the onset of the lesion. In a similar way to the clinical decision making process in manual or other therapies, tissue reactivity is the key. If the tissue in question behaves in an acute manner on assessment, then the lesion is effectively treated with an 'acute' dose. If it behaves as a chronic, less responsive tissue, then treat with a 'chronic' dose. Some patients will present several weeks after an injury or lesion onset, yet the problem exhibits 'acute behaviour' and should treated accordingly. Similarly, some lesions appear to move swiftly into chronic behaviour mode, and these are best managed with a dose estimated for chronic lesions. The key here is to treat what you find at assessment, rather than what the timescale says should be there.

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Ultrasound Treatment Intensity

In a similar way to the pulse ratio decision, the intensity of ultrasound required at the target tissue will vary with the tissue state. The more acute the lesion, the less strong the ultrasound needs to be in order to achieve/maintain the tissue excitement. The more chronic the tissue state, the less sensitive, and hence the greater the intensity required at the lesion in order to instigate a physiological response.

One important factor is that some of the ultrasound energy delivered to the tissue surface will/may be lost before the target tissue (i.e. in the normal or uninjured tissues which lie between the skin surface and the target). In order to account for this, it may be necessary to deliver more at the surface than is required, therefore allowing for some absorption before the lesion, and allowing sufficient remaining ultrasound to achieve the desired effect.

The intensity required at the lesion can be determined from the following table :

Tissue State Intensity required at the lesion W/cm2
Acute 0.1 - 0.3
Sub Acute 0.2 - 0.5
Chronic 0.3 - 0.8

The rate at which ultrasound is absorbed in the tissues can be approximately determined by the half value depth - this is the tissue depth at which 50% of the ultrasound delivered at the surface has been absorbed. The figures used for these estimates are average values in that it absolute values will vary with the thickness of various tissues (e.g. skin, fat, muscle etc). The average 1/2 value depth of 3MHz ultrasound is taken at 2.5cm and that of 1MHz ultrasound as 4.0 cm though there are numerous debates that continue with regards the most appropriate half value depth for different frequencies.

The tables below indicate the intensity required at the skin surface in order to achieve a particular intensity at depth. It is suggested that the intensity required at depth is established first (from the table above), then the most appropriate frequency selected and these two factors are used to determine the surface intensity required.

3MHz Ultrasound                    
1/2 value depth = 2.5cm

Table to indicate the surface intensity (W/cm2) required to achieve a particular intensity at depth using 3MHz ultrasound (it is probably not worth trying to use 3MHz US at tissue depths greater than 2 cm)

  Depth of Lesion (cm)
Intensity required at the lesion (W cm-2) 0.5 1 2 3 4 5 6
  3 MHz
 
1 MHz
 
1.0 1.20 1.40 1.80 1.75 2.00 2.25 2.50
0.9 1.08 1.26 1.62 1.58 1.80 2.03 2.25
0.8 0.96 1.12 1.44 1.40 1.60 1.80 2.00
0.7 0.84 0.98 1.26 1.23 1.40 1.58 1.75
0.6 0.72 0.84 1.08 1.05 1.20 1.35 1.50
0.5 0.60 0.70 0.90 0.88 1.00 1.13 1.25
0.4 0.48 0.56 0.72 0.70 0.80 0.90 1.00
0.3 0.36 0.42 0.54 0.53 0.60 0.68 0.75
0.2 0.24 0.28 0.36 0.35 0.40 0.45 0.50
0.1 0.12 0.14 0.18 0.18 0.20 0.23 0.2

Size of the Lesion

The greater the size of the lesion, the longer the duration of the ultrasound that will be required in order to achieve a particular effect. The most common method to take account of this factor is to estimate the number of times which the ultrasound treatment head to be utilised can be placed over the target tissue.

For example, if the large treatment head is used to treat the anterior capsule of the shoulder, it can be estimated that it will fit twice over the target. Similarly, if the small treatment head is applied over the lateral ligament of the elbow, it may only fit once.

There is not need to measure the treatment head, it is a matter of estimating the number of time the head fits onto the target tissue rather than a millimetre by millimetre measurement.

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Compiling the treatment dose

The final compilation of the treatment dose which is most likely to be effective is based on the principle that one needs to deliver 1 minutes worth of ultrasound energy (at an appropriate frequency and intensity) for every treatment head that needs to be covered.

The size of the treatment area will influence the treatment time, as will the pulse ratio being used.

The larger the treatment area, the longer the treatment will take. The more pulsed the energy output from the machine, the longer it will take to deliver 1 minutes worth of ultrasound energy (there is a greater proportion of time during which the machine gives no output).

Using the tables above, it is possible to estimate the surface intensity required at a particular frequency to achieve sufficient ultrasound at the required depth to gain the desired effect.

Using the information in the previous sections, the following examples may serve to illustrate the point :

Example 1

Ultrasound treatment for an acute lesion of the lateral collateral ligament of the knee

Assuming that on examination, the primary focus of the lesion is determined to be at the anterior portion of the ligament (anterior talo-fibular), the following clinical decisions are made :

The lesion is superficial, hence a 3MHz frequency would be most appropriate

The lesion is acute, thus an intensity of 0.2 W/cm2 should be sufficient to treat the lesion

There is no need to increase the surface dose to allow for loss of ultrasound at depth

The lesion is acute, therefore a pulse ratio of 1:4 will be most appropriate

Using the large treatment head, it is estimated that the target tissue is approximately the same size as the treatment head (i.e. the head fits on to the tissue once)

Working on the principle of 1 minutes worth of ultrasound per treatment head area, the total time taken to treat the lesion will be (1 minute) x (number of times the treatment head fits over the lesion) x (the pulse ratio) which in this instance = (1) x (1) x (5) = 5 minutes.

NOTE ::: IF YOU ARE NOT SURE WHAT TO MULTIPLY BY FOR THE PULSING FACTOR, THEN EASIEST WAY IS TO ADD THE 2 NUMBERS OF THE RATIO TOGETHER AND USE THAT - SO IN THIS CASE PULSE AT 1:4 - - - - ADDS UP TO 5 - - - - - SO MULTIPLY BY 5. IF HAD SET PULSE RATIO AT 1:2, THEN ADDS UP TO 3, SO MULTIPLY BY THREE - EASY AS THAT REALLY.

The final treatment dose will therefore be

3MHz ; 0.2 W/cm2 ; Pulsed 1:4 ; 5 minutes

There is no 'proof' that this is a guaranteed dose, but given the available evidence, it is the dose that is most likely to achieve the intended effect (i.e. activation of the tissue repair process).

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Example 2

Ultrasound treatment of a subacute lesion of the lateral ligament complex of the elbow and superior radioulnar joint

Assuming that on examination, the primary focus of the lesion is determined to be at the lateral ligament of the elbow joint itself together with the lateral portion of the annular ligament of the superior radioulnar joint, the following clinical decisions are made :

The lesion is superficial, hence a 3MHz frequency would be most appropriate

The lesion is sub-acute, thus an intensity of 0.4 W/cm2 should be sufficient to treat the lesion

There is no need to increase the surface dose to allow for loss of ultrasound at depth

The lesion is sub-acute, therefore a pulse ratio of 1:2 will be most appropriate

Using the small treatment head (due to the nature of the surface), it is estimated that the target tissue is approximately twice the size of the treatment head (i.e. the head fits on to the tissue twice)

Working on the principle of 1 minutes worth of ultrasound per treatment head area, the total time taken to treat the lesion will be (1 minute) x (number of times the treatment head fits over the lesion) x (the pulse ratio) which in this instance = (1) x (2) x (3) = 6 minutes.

The final treatment dose will therefore be

3MHz ; 0.4 W/cm2 ; Pulsed 1:2 ; 6 minutes

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Example 3

Ultrasound treatment of a chronic lesion of the anterior capsule of the shoulder (glenohumeral joint

Assuming that on examination, the primary focus of the lesion is determined to be at the anterior capsule of the glenohumeral joint, the following clinical decisions are made :

The lesion is not superficial, hence a 1MHz frequency would be most appropriate

The lesion is chronic, thus an intensity of 0.5 W/cm2 should be sufficient to treat the lesion

There IS a need to increase the surface dose to allow for loss of ultrasound at depth, and using the tables above, it is estimated that the required surface dose will need to be 0.75 W/cm2 (though of course this will depend on the size of the patient – it is not a universal formula)

The lesion is chronic, therefore a pulse ratio of 1:1 will be most appropriate

Using the large treatment head, it is estimated that the target tissue is approximately twice the size of the treatment head (i.e. the head fits on to the tissue twice)

Working on the principle of 1 minutes worth of ultrasound per treatment head area, the total time taken to treat the lesion will be (1 minute) x (number of times the treatment head fits over the lesion) x (the pulse ratio) which in this instance = (1) x (2) x (2) = 4 minutes.

The final treatment dose will therefore be

1MHz ; 0.75 W/cm2 ; Pulsed 1:1 ; 4 minutes

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Example 4

Ultrasound treatment of a very chronic lesion of the gastrocnemius/TA musculotendinous junction

Assuming that on examination, the primary focus of the lesion is determined to be at a reasonably well defined area of the MT junction, the following clinical decisions are made :

The lesion is relatively superficial, hence a 3MHz frequency would be most appropriate (this may not be true for some patients)

The lesion is very chronic, thus an intensity of at least 0.6 W/cm2 will probably be required to treat the lesion

There IS a need to increase the surface dose to allow for loss of ultrasound at depth, and using the tables above, and assuming the MT junction is estimated at 1cm depth, using 3MHz, the intensity will need to be set at 0.84 W/cm2 to achieve the 0.6 W/cm2 required at the lesion

The lesion is particularly chronic, therefore a continuous mode will be most appropriate

Using the large treatment head, it is estimated that the target tissue is approximately three times the size of the treatment head.

 

Working on the principle of 1 minutes worth of ultrasound per treatment head area, the total time taken to treat the lesion will be (1 minute) x (number of times the treatment head fits over the lesion) x (the pulse ratio) which in this instance = (1) x (3) x (1) = 3 minutes.

The final treatment dose will therefore be

3MHz ; 0.84 W/cm2 ; Continuous; 3 minutes


There are clearly other ways of working out a dose, and I would not pretend for one moment, that this is the only way, nor even necessarily the 'best' way, but it is a method of taking the evidence that is available out there, looking at the doses that work (and those that do not) and using that evidence to generate the decision making flowchart - which is all I did in this instance.

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Resources

Courses

Courses

A wide range of Electrotherapy Courses are delivered throughout the UK, Europe and Worldwide with varying content, aims and duration.

Books

Books

Current books on Electrotherapy with brief descriptions and links to Amazon pages for purchase.

FAQs: Prof. Tim Watson

FAQs: Prof. Tim Watson

Some common answers to the most frequently asked questions on Electrotherapy, particularly in the area of Contraindications.